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miR‑505 suppresses prostate cancer progression by targeting NRCAM
日期: 2020-08-31 10:21 浏览: 969
Previous researchers have demonstrated thatmicroRNA-505 (miR-505) is negatively correlated withprogression in various malignancies. However, the detailedfunction and molecular mechanisms of miR-505 have yet tobe completely elucidated in prostate cancer (PCa). The presentstudy initially identified the potential role of miR‑505 in PCausing in vitro experiments, and demonstrated that restorationof miR-505 inhibited proliferation, invasion and migration,yet induced cell cycle arrest and promoted apoptosis in PCacells. The present study also demonstrated that the expressionof neuron-glial-related cell adhesion molecule (NRCAM)was markedly upregulated in PCa cells when compared withbenign prostate epithelium. A luciferase reporter assay demonstrated that miR-505 directly targeted NRCAM in PCa cells.In addition, NRCAM stimulation antagonized the inhibitoryeffects of miR-505 on the proliferation, migration, and invasion of PCa cells. Furthermore, lower levels of miR-505 andhigher levels of NRCAM may serve as a predictor of worsebiochemical recurrence-free survival or disease-free survivalin patients with PCa. In conclusion, the present study revealedthe inhibitory effects of miR-505 on PCa tumorigenesis, whichpotentially occur by targeting NRCAM. The combined analysis of NRCAM and miR-505 may predict disease progressionin patients with PCa following radical prostatectomy.